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中国化学会第十一届全国磷化学化工学术讨论会暨空间生命起源与进化专业委员会年会 会议通知
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学术报告:

报告题目:Molecular Genetic Testing and the Future of Clinical Genetic Diagnosis for Rare Diseases

报告人:周岩 博士(牛津大学Weatherall 分子医学研究所)

时间:2017年4月21日(周五)9:00-10:00

报告地点:逸夫楼C座314会议室

目标

实验室研究工作的定位是以应用基础研究为主、并向基础与应用研究延伸。本实验室将以我省主要作物、畜禽及相关致病微生物的基因组、转录组、蛋白质组、代谢组和表型组为研究对象,瞄准学科前沿将各种“组学”技术与信息技术相结合,分别从基因组信息挖掘、蛋白质序列结构功能分析、代谢组分析与药物设计、表型组分析与设计育种和生物信息技术研发五个方面开展全方位的研究,深入解读各种“组学”产生的海量生物学数据,为动植物育种、种质资源保护、农业病虫害监测和防治提供新理论、新技术和新方法,为确保我省乃至周边省份的粮食安全做出贡献。

研究成果
1) Jing Guo, Gang Cheng, Xiang-Yong Gou, Feng Xing, Sen Li, Yi-Chao Han, Long Wang, Jia-Ming Song, Cheng-Cheng Shu, Shou-Wen Chen*, Ling-Ling Chen*. Comprehensive transcriptome and improved genome annotation of Bacillus licheniformis WX-02. FEBS Lett., 2015, 589: 2372-2381.
2) Xiao-Tao Wang, Peng-Fei Dong, Hong-Yu Zhang, Cheng Peng*. Structural heterogeneity and functional diversity of topologically associating domains in mammalian genomes. Nucleic Acids Research, 2015, 43(15):7237-7246.
3) Xiaoxia Yang, Jia Wang, Jun Sun, Rong Liu*. SNBRFinder: A sequence-based hybrid algorithm for enhanced prediction of nucleic acid-binding residues. PLoS ONE. 2015, 10(7): e0133260.
4) Xiao-Pan Hu, Yi Yang, Bin-Guang Ma*, Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability. Sci Rep. 2015 Jun 9;5:11113. doi: 10.1038/srep11113.
5) Ting Xie, Jue-Fei Zheng, Sheng Liu, Cheng Peng, Yong-Ming Zhou, Qing-Yong Yang*, Hong-Yu Zhang. De novo plant genome assembly based on chromatin interactions: A case study of Arabidopsis thaliana. Mol. Plant, 2015, 8: 489-492.
6) Ting Xie, Liang-Yu Fu, Qing-Yong Yang, Heng Xiong, Hong-Rui Xu, Bin-Guang Ma*, Hong-Yu Zhang*. Spatial features for Escherichia coli genome organization. BMC Genomics, 2015, 16: 37.
7) Yao W, Li G, Zhao H, Wang G, Lian X, Xie W*. Exploring the rice dispensable genome using a metagenome-like assembly strategy. Genome Biology, 2015, doi: 10.1186/s13059-015-0757-3
8) Guoping Nie, Yong Li, Feichi Wang, Siwen Wang, Xuehai Hu*. A novel fractal approach for predicting G-protein–coupled receptors and their subfamilies with support vector machines. Bio-Medical Materials and Engineering, 26 (s1), 1829-1836, 2015.
9) Shou-Kai Kang, Bai-Xue Chen, Tian Tian, Xi-Shuai Jia, Xin-Yi Chu, Rong Liu, Peng-Fei Dong, Qing-Yong Yang, Hong-Yu Zhang*. ATP selection in a random peptide library consisting of prebiotic amino acids. Biochem. Biophys. Res. Commun., 2015, 466: 400-405.
10) Cheng Wang, Zhi-Luo Deng, Zhi-Ming Xie, Xin-Yi Chu, Ji-Wei Chang, De-Xin Kong, Bao-Ju Li, Hong-Yu Zhang, Ling-Ling Chen*. Construction of a genome-scale metabolic network of the plant pathogen Pectobacterium carotovorum provides new strategies for bactericide discovery. FEBS Lett., 2015, 589: 285-294.
11) Yaping Lu, Yemao Liu, Xiaohui Niu, Qingyong Yang, Xuehai Hu, Hong-Yu Zhang, Jingbo Xia*. Systems genetic validation of the SNP-metabolite association in rice via metabolite-pathway-based phenome-wide association scans. Front. Plant Sci., 2015, 6: 1027.
12) Xiaojuan Qi, Wenjun Deng, Min Gao, Bangqiang Mao, Shengzhen Xu, Changshui Chen, Qing Ye Zhang*. Novel lead compound optimization and synthesized based on the target structure of of Xanthomonasoryzaepv. oryzaeGlmU. Pestic. Biochem. Phys.122, 22–28, 2015(support by Nos. 30900935 and 21173092 and No. 2011PY039)
13) Wanneng Yang, Zilong Guo, Chenglong Huang, Ke Wang, Ni Jiang, Hui Feng, Guoxing Chen, Qian Liu and Lizhong Xiong*. Genome-wide association study of rice (Oryza sativa L.) leaf traits with a high-throughput leaf scorer. Journal of Experimental Botany, 2015. doi:10.1093/jxb/erv100
14) Lida Zhu, Fuxi Zhu*. Identification association of drug-disease by using functional gene module for breast cancer. BMC Medical Genomics 8. Suppl 2 (2015): S3. (会议论文)
15) Xianqin Hu, Xiaozhe Fu, Ningqiu Li, Xingxing Dong, Lijuan Zhao, Jiangfeng Lan, Wei Ji, Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Lin*.Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish & shellfish immunology (2015). 7
16) Zhi-Hu Pei, Ting Xie, Qing-Yong Yang*, Qing-Ye Zhang*,Hong-Yu Zhang, Novel Isoniazid-and Ethionamide-resistance loci in mycobacterium tuberculosis identified by phenome-wide association scans[C]//Bioinformatics and Biomedicine (BIBM), 2015 IEEE International Conference on. IEEE, 2015: 1129-1132.(会议论文)
17) Qiang Wang, Jun Gao, Dongju Zhang, Chengbu Liu*, A theoretical model investigation of peptide bond formation involving two water molecules in ribosome supports the two-step and eight membered ring mechanism. Chemical Physics, 2015, 450: 1-11.
18) Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen,Xiaoling Liu, Yang Zhou*, Li Lin*. Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas sobria[J]. International journal of molecular sciences, 2015, 16(5): 10997-11012.
19) Jing Guo, Hong Zhang1, Cheng Wang, Ji-Wei Chang, Ling-Ling Chen*, Construction and analysis of a genome-scale metabolic network for Bacillus licheniformis WX-02[J]. Research in Microbiology, 2016.
20) Li-Da Zhu, Chang-Shou He,Ye-Mao Liu,Yuan Quan, Jing Chen,Qiang Zhu*,Qing-Ye Zhang*, Hong-Yu Zhang, Asystems chemical biology approach to identify targets of antibacterial agents: A case study of Chelerythrine and Rhein[C]//Bioinformatics and Biomedicine (BIBM), 2015 IEEE International Conference on. IEEE, 2015: 1047-1056.
21) Xiu-Zhe Zhang*, Yuan Quan, and Guang-Yan Tang*. Medical genetics-based drug repurposing for Alzheimer's disease[J]. Brain research bulletin, 2015, 110: 26-29.
22) Yuantao Xu, Guizhi Wu, Baohai Hao, Lingling Chen, Xiuxin Deng, Qiang Xu*. Identification, characterization and expression analysis of lineage-specific genes within sweet orange (Citrus sinensis). BMC genomics, 2015, 16(1): 995.
23) Yuduan Ding, Jiwei Chang, Qiaoli Ma, Lingling Chen, Shuzhen Liu, Shuai Jin, Jingwen Han, Rangwei Xu, Andan Zhu, Jing Guo, Yi Luo, Juan Xu, Qiang Xu, YunLiu Zeng, Xiuxin Deng and Yunjiang Cheng*. Network Analysis of Postharvest Senescence Process in Citrus Fruits Revealed by Transcriptomic and Metabolomic Profiling. Plant physiology, 2015, 168(1): 357-376.
24) Hao Zhang, Jun Sun, Jing Ye, Usama Ashraf, Zheng Chen, Bibo Zhu,WenHe, Qiuping Xu, Yanming Wei, Huanchun Chen, Zhen F. Fu, Rong Liu*,Shengbo Cao. Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response. Journal of proteome research, 2015, 14(12): 5157-5168.
25) Hongchu Wang, Xuehai Hu*. Accurate prediction of nuclear receptors with conjoint triad feature,BMC bioinformatics, 2015, 16(1): 1.
26) Lingfeng Duan, Chenglong Huang, Guoxing Chen, Lizhong Xiong, Qian Liu, Wanneng Yang*. High-throughput estimation of yield for individual rice plant using multi-angle RGB imaging, 2015(EI收录, in press)
梁秀英,李小昱,杨万能*。奇异数据筛选法在玉米籽粒蛋白质近红外光谱检测中的应用。激光生物学报,2015,24(1):38-45. (中文核心)
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3. Alexander Goncearenco, Bin-Guang Ma, Igor N. Berezovsky*. (2014) Molecular mechanisms of adaptation emerging from the physics and evolution of nucleic acids and proteins. Nucleic Acids Res., 42(5): 2879-92.
4. Jieli Peng, Baohai Hao, Liu Liu, Shanming Wang, Binguang Ma, Yi Yang, Fuli Xie, Youguo Li*. (2014) RNA-Seq and microarrays analyses reveal global differential transcriptomes of Mesorhizobium huakuii 7653R between bacteroids and free-living cells. PLoS One., 9(4): e93626.
5. Shanming Wang, Baohai Hao, Jiarui Li, Huilin Gu, Jieli Peng, Fuli Xie, Xinyin Zhao, Christian Frech, Nansheng Chen*,Binguang Ma*, Youguo Li*. (2014) Whole-genome sequencing of Mesorhizobium huakuii 7653R provides molecular insights into host specificity and symbiosis island dynamics. BMC Genomics, 15:440.
6. Heng Xiong, Yi Yang, Xiao-Pan Hu, Yi-Ming He, Bin-Guang Ma*. (2014) Sequence determinants of prokaryotic gene expression level under heat stress. Gene, 551(1): 92-102.
7. 彭城, 李国亮, 张红雨, 阮一骏*.(2014) 染色质三维结构重建及其生物学意义.中国科学:生命科学, 8: 794-802.
8. Jia Wang#, Dijun Chen#, Yang Lei#, Ji-Wei Chang, Bao-Hai Hao, Feng Xing, Sen Li, Qiang Xu, Xiu-Xin Deng, Ling-Ling Chen*. (2014) Citrus sinensis annotation project (CAP): a comprehensive database for sweet orange genome. PLoS One, 9(1): e87723.
9. Yang Lei, Li Lu, Hai-Yang Liu, Sen Li, Feng Xing, Ling-Ling Chen*. (2014) CRISPR-P: a web tool for synthetic single-guide RNA design of CRISPR-system in plants. Mol Plant., 7(9):1494-6.
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11. Yu-Duan Ding, Ji-Wei Chang, Jing Guo, DiJun Chen, Sen Li, Qiang Xu, Xiu-Xin Deng, Yun-Jiang Cheng*, Ling-Ling Chen*. (2014) Prediction and functional analysis of the sweet orange protein-protein interaction network. BMC Plant Biol., 14:213.
12. Wanneng Yang#, Zilong Guo#, Chenglong Huang#, Lingfeng Duan#, Guoxing Chen#, Ni Jiang, Wei Fang, Hui Feng, Weibo Xie, Xingming Lian, Gongwei Wang, Qingming Luo, Qifa Zhang, Qian Liu*, Lizhong Xiong* (2014) Combining high-throughput phenotyping and genome-wide association studies to reveal natural genetic variation in rice. Nat Commun., 5:5087.
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15. Hui-Yong Sun, Ting-Jun Hou*, Hong-Yu Zhang*. (2014) Finding chemical drugs for genetic diseases. Drug Discov. Today, 19: 1836-1840.
16. Yuan Quan, Zhong-Yi Wang, Min Xiong, Zheng-Tao Xiao, Hong-Yu Zhang*. (2014) Dissecting traditional Chinese medicines by omics and bioinformatics. Nat. Prod. Commun., 9: 1391-1396.
17. Xiu-Zhen Zhang*, Ling Wang, Dong-Wu Liu, Guang-Yan Tang, Hong-Yu Zhang. (2014) Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J. Med. Food, 17: 955-962.
18. Bin Li, Min Xiong, Hong-Yu Zhang*. (2014) Elucidating polypharmacological mechanisms of polyphenols by gene module profile analysis. Int. J. Mol. Sci., 15: 11245-11254.
19. You-Min Sun, Zheng-Tao Xiao, Hong-Yu Zhang*. (2014) Structure-activity relationships of tanshinones in activating Nrf2. A DFT study and implications for multifunctional antioxidant discovery. Nat. Prod. Commun., 9: 453-454.
20. Zheng-Tao Xiao, Qiang Zhu, Hong-Yu Zhang*. (2014) Identifying antibacterial targets of flavonoids by comparative genomics and molecular modeling. Open J. Genomics, 3: 1.
21. Dijun Chen, Liang-Yu Fu, Zhao Zhang, Guoliang Li, Hang Zhang, Li Jiang, Andrew P. Harrison, Hugh P. Shanahan, Christian Klukas, Hong-Yu Zhang, Yijun Ruan*, Ling-Ling Chen*, Ming Chen*. Dissecting the chromatin interactome of microRNA genes. Nucleic Acids Res., 2014, 42: 3028-3043.
22. Min Xiong, Bin Li, Qiang Zhu, Yun-Xing Wang, Hong-Yu Zhang*. (2014) Identification of transcription factors for drug-associated gene modules and biomedical implications. Bioinformatics, 30: 305-309.
23. Zhong-Yi Wang, Yuan Quan, Hong-Yu Zhang*. (2014) Medical genetic inspirations for anticancer drug repurposing. Trends Pharmacol. Sci., 35: 1-3.
24. Haodong Chen#, Weibo Xie#, Hang He#, Huihui Yu#, Wei Chen, Jing Li, Renbo Yu, Yue Yao, Wenhui Zhang, Yuqing He, Xiaoyan Tang*, Fasong Zhou*, Xing Wang Deng*, Qifa Zhang*. (2014) A high-density SNP genotyping array for rice biology and molecular breeding. Mol Plant.7(3): 541-53.
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26. Wei Chen#, Yanqiang Gao#, Weibo Xie#, Liang Gong#, Kai Lu#, Wensheng Wang#, Yang Li, Xianqing Liu, Hongyan Zhang, Huaxia Dong, Wan Zhang, Lejing Zhang, Sibin Yu, Gongwei Wang, Xingming Lian*, Jie Luo*. (2014) Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. Nat Genet., 46(7): 714-21.
27. Jingnan Jin, Xiaojuan Qi, Dandan Yao, Bangqiang Mao, Jianhong Li, Qingye Zhang*, Changshui Chen*. (2014) Rational design and screening study of novel lead compound based on acetohydroxyacid synthase structure. Chem Biol Drug Des., 84(3):316-24.
28. Xia-Li Yue, Hu Li, Shuang-Shuang Liu, Qing-Ye Zhang, Jing-Jing Yao, Fei-Yan Wang. (2014) N-Fluorinated phenyl-N′-pyrimidyl urea derivatives: Synthesis, biological evaluation and 3D-QSAR study. Chinese Chem. Lett., 25(7): 1069–1072.