Protein folding is a process that a protein transforms from it denatured state to its native state with specific biological function. Folding rate of a protein measures how fast is the tranformation process and folding type indicates the dynamic behavior of this process. Protein folding is also an important research field of molecular biology. FDserver is developed to facilitate protein folding research.
The present server consists of three components: CIpred, SBpred and TPcalc. TPcalc is a calculator that can calculate a variety of topological parameters of protein 3D structure. SBpred is a structure-based predictor of protein folding rate and folding type. CIpred can predict protein folding rate and folding type from the primary sequence of a protein, without the need of structure information, which is particularly useful to the "raw" protein sequence such as a sequence translated from its coding gene that comes from a newly sequenced genome. Click on the colored circle below to access the corresponding service.
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[1] Bin-Guang Ma, Jian-Xiu Guo, Hong-Yu Zhang.(2006) Direct correlation between proteins' folding rates and their amino acid compositions: an ab initio folding rate prediction. Proteins: Structure, Function, and Bioinformatics 65, 362-372; DOI: http://dx.doi.org/10.1002/prot.21140.
[2] Bin-Guang Ma, Ling-Ling Chen, Hong-Yu Zhang.(2007) What determines protein folding type? An investigation of intrinsic structural properties and its implications for understanding folding mechanisms. Journal of Molecular Biology 370, 439-448. DOI: http://dx.doi.org/10.1016/j.jmb.2007.04.051.
Links:TCD server: Protein Folding Rate Prediction based on Total Contact Distance.
FOLD-RATE server: Prediction of Protein Folding Rates from Amino Acid Sequence.
K-Fold server: Predictor of the Protein Folding Mechanism and Rate.
PFD: Protein Folding Database.
Last Updated: 2007-8-5, ©SDBI.